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Can I Take Antihistamines When Pregnant?

Hayfever, hives, skin reactions, and allergies don't stop just because you're pregnant. If you're wondering whether you can take antihistamines during pregnancy, the short answer is: some are considered safe, but you should always check with your GP or pharmacist before taking any. Here's what you need to know.

Quick Answer

Antihistamines in pregnancy: Some antihistamines are considered safe in pregnancy. Loratadine and cetirizine are the ones most commonly used, and they are generally regarded as lower-risk non-drowsy options. Chlorphenamine (Piriton) is an older, drowsy-type antihistamine that is sometimes recommended when the benefits outweigh the risks. Always confirm with your GP or pharmacist before taking any antihistamine.

Which Antihistamines Are Considered Safer in Pregnancy?

Not all antihistamines are the same. They fall broadly into two groups: non-drowsy (second-generation) and drowsy (first-generation).

Non-drowsy antihistamines include loratadine and cetirizine. These are the types most frequently used in pregnancy and are generally considered lower risk, particularly after the first trimester. The NHS advises that loratadine is the preferred choice during pregnancy when an antihistamine is needed, but they still recommend speaking to a pharmacist or GP first.

Drowsy antihistamines include chlorphenamine (sold as Piriton). Chlorphenamine has been available for longer and there is more historical use data in pregnancy. It may sometimes be recommended by a healthcare professional, particularly for short-term use, but it is not usually the first choice.

Antihistamines to avoid during pregnancy include promethazine (found in some sleep aids and travel sickness remedies) at higher doses near the end of pregnancy, as it can affect newborns. Always check the label and ask your pharmacist.

The first trimester is generally when most caution is advised around any medication, as the baby's organs are forming. This doesn't mean antihistamines cause harm — it means there's less certainty, and a brief conversation with your GP or pharmacist takes only a few minutes.

Why You Might Need an Antihistamine in Pregnancy

Common reasons pregnant women reach for antihistamines include:
  • Hayfever and seasonal allergies — pregnancy can make nasal symptoms worse due to hormonal changes causing nasal congestion independently of allergies
  • Skin reactions, hives, or eczema flares — some women find their skin becomes more reactive during pregnancy
  • Insect stings or bites causing localised swelling and itching
  • Food allergies — if you've had a mild allergic reaction
  • Travel sickness — some antihistamines are used for nausea, but there are pregnancy-specific options worth discussing with your GP

It's worth telling your pharmacist you are pregnant before picking anything off the shelf, as even familiar medicines can have different recommendations during pregnancy.

NHS Guidance

The NHS advises that you should always check with a healthcare professional before taking any medication in pregnancy, including over-the-counter medicines. This is not because all medicines are harmful — many are not — but because recommendations can depend on your stage of pregnancy, your health history, and whether you have other conditions being managed.

Your community pharmacist is a good first port of call for mild symptoms. They can advise on the most appropriate antihistamine for your situation and flag any interactions with other medicines you might be taking. Your GP or midwife can also offer guidance, particularly if your allergy symptoms are severe or ongoing.

Non-Medication Alternatives for Allergies in Pregnancy

If you'd prefer to manage mild allergy symptoms without medication, or while you wait to speak to a healthcare professional, there are some practical options:
  • Nasal rinses or saline nasal spray — can relieve stuffiness without any systemic effect
  • Wrap-around sunglasses — reduce pollen reaching your eyes when hayfever is the issue
  • Staying indoors on high pollen count days and showering when you come in
  • Cold compresses for itchy skin or hives
  • Antihistamine eye drops — some are suitable during pregnancy; ask your pharmacist

These won't suit every situation, and if symptoms are significantly affecting your quality of life or sleep, talking to your GP about a safe antihistamine is entirely reasonable.

Frequently Asked Questions

### What if I already took antihistamines before knowing I was pregnant?

Don't panic. Taking a short course of most over-the-counter antihistamines before you knew you were pregnant is unlikely to cause harm. Contact your GP or midwife for reassurance and mention it at your booking appointment. In the vast majority of cases, accidental medication exposure early in pregnancy is not a cause for concern, but your midwife will want to know so it's documented.

Can I buy antihistamines over the counter while pregnant?

Yes, but always tell the pharmacist you're pregnant before buying any medication. They can advise which product is most appropriate, confirm the correct dose, and suggest alternatives if needed. Pharmacists are trained to give medication advice in pregnancy and it is one of the most common questions they are asked.

Is it safe to take antihistamines every day throughout pregnancy?

This depends on the antihistamine and your individual circumstances. For most people, occasional use of loratadine or cetirizine is considered low risk. Daily long-term use is a question best discussed with your GP, who can weigh up the benefits and any potential risks for your specific situation.

Always speak to your midwife or GP for personal advice about medication in pregnancy.

This article is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider.

Last reviewed: June 2026

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